Gene editing therapy may permanently inactivate cancer cells

According to a recent report in the Journal of scientific progress, a study by Tel Aviv University in Israel has proved that CRISPR / cas9 system is very effective in treating invasive cancer, which is an important step in finding a cure for cancer. Crispr-lnp, a novel delivery system based on lipid nanoparticles, has been developed by researchers, which can specifically target cancer cells and destroy them through gene manipulation. The system carries a genetic messenger that encodes the CRISPR enzyme cas9, which acts as a molecular scissors to cut the DNA of cancer cells, making them ineffective and permanently preventing replication. The associate director of the Institute of biomedical research and development of the Institute of Biomedical Sciences, Dr. This method is not chemotherapy, there are no side effects, and cancer cells treated with this method will never be active again. < / P > < p > in order to verify the feasibility of using this technology to treat cancer, Professor peel and his team chose two of the most lethal cancers glioblastoma and metastatic ovarian cancer to carry out research. Glioblastoma is the most invasive type of brain cancer. The life expectancy after diagnosis is 15 months and the 5-year survival rate is only 3%. Studies have shown that a single treatment with crispr-lnp can double the average life expectancy of mice with glioblastoma, thus increasing the overall survival rate by about 30%. Ovarian cancer is one of the main causes of female mortality and the most fatal cancer in female reproductive system. When metastases spread throughout the body, most patients are diagnosed with advanced cancer. Although treatment has improved in recent years, only one-third of patients may survive. Studies have shown that crispr-lnp can increase the overall survival rate by 80% in mice with metastatic ovarian cancer. Professor peile said that CRISPR genome editing technology, which can identify and change any gene fragment, has revolutionized the ability to destroy, repair and even replace genes in a personalized way. Although this technology is widely used, its clinical practice is still in its infancy. It is urgent to develop an effective delivery system to deliver CRISPR to target cells safely and accurately. The delivery system developed by the new research can target the DNA responsible for the survival of cancer cells, which is an innovative method for invasive cancer that has no effective treatment at present. < / P > < p > the researchers pointed out that by demonstrating its potential in the treatment of two invasive cancers, the technology opens up many new possibilities for the treatment of other types of cancer, as well as rare genetic and chronic viral diseases. < p > < p > cancer is known as the “king of all diseases”. It brings people suffering, suffering and high mortality, which makes people talk about cancer pale. Looking for effective therapies to overcome various cancers is still the frontier of medicine. As a popular biological experiment tool in recent years, what role can CRISPR system play? The study offers exciting answers.